Clearance kinetics of haptoglobin-hemoglobin complex in the human.
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چکیده
منابع مشابه
Heterotropic Effect of β-lactam Antibiotics on Antioxidant Property of Haptoglobin) 2-2(-Hemoglobin Complex
Haptoglobin (Hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. Hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. As an important consequence, Haptoglobin-Hemoglobin complex (Hp-Hb) shows considerable antiox...
متن کاملHeterotropic Effect of β-lactam Antibiotics on Antioxidant Property of Haptoglobin) 2-2(-Hemoglobin Complex
Haptoglobin (Hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. Hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. As an important consequence, Haptoglobin-Hemoglobin complex (Hp-Hb) shows considerable antiox...
متن کاملBinding of acellular, native and cross-linked human hemoglobins to haptoglobin: enhanced distribution and clearance in the rat.
It is well established that hemoglobin resulting from red cell lysis binds to haptoglobin in plasma to form a complex. The increased molecular size precludes its filtration by the kidneys, redirecting it toward hepatocellular entry. Chemically cross-linked hemoglobins are designed to be resistant to renal excretion, even in the absence of haptoglobin. The manner in which binding to haptoglobin ...
متن کاملKinetics and Mechanism of Complex Formation between Hemoglobin and Haptoglobin*
The interaction between human hemoglobin and haptoglobin has been followed by measuring the quenching of haptoglobin fluorescence associated with complex formation. The effects of varying the concentration of the reactants suggest that hemoglobin tetramers do not react with haptoglobin, but that hemoglobin subunits are involved. Separated a! chains of hemoglobin react with haptoglobin; although...
متن کاملReceptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging.
Haptoglobin, the haptoglobin-hemoglobin receptor CD163, and the heme oxygenase-1 are proteins with a well-established function in the clearance and metabolism of "free" hemoglobin released during intravascular hemolysis. This scavenging system counteracts the potentially harmful oxidative and NO-scavenging effects associated with "free" hemoglobin, and, furthermore, elicits an anti-inflammatory...
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ورودعنوان ژورنال:
- Blood
دوره 20 شماره
صفحات -
تاریخ انتشار 1962