Metabolic reprogramming of bone marrow stromal cells by leukemic extracellular vesicles in acute lymphoblastic leukemia.
نویسندگان
چکیده
From: Children’s Cancer Group, Institute of Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, United Kingdom; Manchester Centre for Cellular Metabolism, Institute of Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, United Kingdom; Tata Medical Center, Kolkata, India, Tata Translational Cancer Research Centre, Kolkata, India.
منابع مشابه
Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia
Despite the high cure rates in childhood acute lymphoblastic leukemia (ALL), relapsed ALL remains a significant clinical problem. Genetic heterogeneity does not adequately explain variations in response to therapy. The chemoprotective tumor microenvironment may additionally contribute to disease recurrence. This study identifies metabolic reprogramming of leukemic cells by bone marrow stromal c...
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ورودعنوان ژورنال:
- Blood
دوره 128 3 شماره
صفحات -
تاریخ انتشار 2016