Cancer biomarkers: easier said than done.

From human to mouse and back: 'tumorgraft' models surge in popularity.

resistance to gemcitabine, the standard therapy for pancreatic cancer, and sensitivity to mitomycin C, a rarely used treatment. The patient — who fi rst failed gemcitabine therapy — received mitomycin C and has been in remission for more than 2 years. The trial’s principal investigator, Manuel Hidalgo , M.D., Ph.D., stressed that tumorgrafts, at present, can be of only limited use for individua...

Biomarker boom slowed by validation concerns.

By many accounts, the brave new worlds of genomics and proteomics— and their accompanying technologies— have ushered in a new era of cancer biomarker research. Researchers in cancer detection, diagnosis, and treatment all have a vested interest in discovering these proteins and small molecules that are telltale signs of early cancer, characteristics that make a type of cancer unique, or markers...

The Formalization of Medical Protocols: Easier Said than Done. the Formalization of Medical Protocols: Easier Said than Done

i-Abstract The role of medical protocols is becoming more and more important in the medical field. Within the Protocure project it has been shown that the quality of medical protocols can be improved by formalization, something much easier said than done. The formalization turns out to be a very time-consuming task resulting in a formal protocol that is much more complex than the original versi...

Author's response to reviews Title: Easier said than done: applying the Ecohealth principles to a study of heavy metals exposure among indigenous communities of the Peruvian Amazon Authors:

Bench marking and performance management in neonatal care: easier said than done!