A Systematic Study on the Self-Assembly Behaviour of Multi Component Fmoc-Amino Acid-Poly(oxazoline) Systems
نویسندگان
چکیده
We report a systematic study of a modular approach to create multi-component supramolecular nanostructures that can be tailored to be both enzyme and temperature responsive. Using a straightforward synthetic approach we functionalised a thermal responsive polymer, poly(2-isopropyl-2-oxazoline), with fluorenylmethoxycarbonyl-amino acids that drive the self-assembly. Depending on the properties of appended amino acids, these polymers undergo substantial morphological changes in response to the catalytic action of alkaline phosphatase.
منابع مشابه
Crystallisation-driven self-assembly of poly(2-isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline) above the LCST.
The solution behaviour in water of a polyoxazoline-type block copolymer, namely poly(2-isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline), denoted as P(iPrOx-b-MeOx), above the lower critical solution temperature (LCST) of the PiPrOx block was exploited to induce a temporary or permanent self-assembly. Spherical micelles were first obtained and could be disassembled in a reversible manner ...
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تاریخ انتشار 2012