Dev120154 367..372

نویسندگان

  • Raymond Teck Ho Lee
  • Zhonghua Zhao
  • Philip W. Ingham
چکیده

The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends acrossmany fields, fromevo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signallingmechanisms, highlighting the similarities and differences between species.

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منابع مشابه

Noël du Fail, Cardano, and the Paris Medical Faculty

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تاریخ انتشار 2016