Lipid Profile of Hypertensive Type 2 Diabetic over weight and Obese Patients in Bangladeshi Population

Diabetes mellitus, a major health concern throughout the world, is often coexisting with obesity, hypertension and dyslipidemia. Several studies have shown that dyslipidemia and hypertension are the major two contributing risk factors of CVD. But interplay among them still to be elucidated. So the present study was aimed to evaluate the lipid abnormalities among hypertensive-overweight to obese type 2 diabetic Bangladeshi population. Hypertension was defined as systolic blood pressure (SBP) ≥140 mmHg and/or diastolic (DBP) ≥90 mmHg. Obese and overweight was defined as BMI (30.0-34.9 and 25.0-29.9). Demographic and clinical data, body mass index (BMI) and fasting blood samples were taken to estimate the lipid profile. Serum glucose was estimated by glucose oxidase, Serum total cholesterol(T Chol), Serum high density lipoprotein-cholesterol (HDL-c), Serum triglycerides(TG) by enzymatic colorimeter test and serum low density lipoprotein-cholesterol (LDL-c) was determined by using Friedwald’s formula. Appropriate statistical tools were used to calculate statistical difference using SPSS for windows Version 10. All the study subjects were aged matched. Body mass index (BMI) in all groups was significantly higher compared to the controls (P<0.001). Serum TG level were significantly higher in over weight hypertensive type 2 diabetics (HTDOW) and obese hypertensive type 2 diabetics (HTDOB) patients compared with their overweight and obese counterpart respectively (P <0.001, P=0.007). In over weight type 2 DM subjects, the mean TG level was higher (P = 0.041) in hypertensive male and female as compared to their normotensive counterpart. On the other hand, in Obese DM subjects, Mean TG level was significantly higher only in hypertensive females as compared to normotensive females and males (P = 0.001 and P = 0.049 respectively). Serum Total cholesterol level didn’t show any significant difference among the study subjects except obese –hypertensive type2 DM female subjects as compared to normotensive female counterpart (P=0.008). From the above study, it can be concluded that dyslipidemia especially hypertriglyceridemia exists in hypertensive overweight to obese type2 DM. Hypertriglyceridemia may be associated with hypertension.