Adrenal Medulla Autografts
نویسنده
چکیده
In 1959, experiments were begun to provide a more physiological and permanent pacemaker for chronic heart block by placing an autotransplant of either adrenal medulla or thyroid gland into the ventricular myocardium of dogs with complete heart block. The original concept was that the small area of myocardium surrounding the endocrine transplant would be stimulated by relatively high local concentrations of the respective hormones. Thus, the electrical activity of this area of myocardium might be increased to such a degree that it would become the dominant pacemaker for the ventricle and result in a faster heart rate.
منابع مشابه
Adrenal medulla autografts in Parkinson's disease: a proposed mechanism of action.
Concepts emerging from experimental manipulations of neurobiological systems in vivo and in vitro may provide explanations for some clinical observations following adrenal medulla autografting in patients with Parkinson's disease. These concepts are reviewed, and a proposed mechanism of action of adrenal autografts in Parkinson's disease is advanced.
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Adrenal medulla grafts in the lateral ventricle reduce the behavioral manifestations of striatal dopamine depletion in an animal model of Parkinson's disease. Using microdialysis in freely moving rats, the present experiments determined that dopamine was not detectable in cerebrospinal fluid (CSF). However, adrenal medulla grafts were associated with an increase in dopamine turnover and ampheta...
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Transplants of neural tissue have been used for nearly 100 years in order to clarify the mechanisms that underlie development and regeneration of the nervous system. With reports from Sweden and Mexico that autografts of adrenal medulla produce at least transient and perhaps dramatic improvement in patients severly disabled by Parkinson's disease, the techniques of neural transplantation have ...
متن کاملAdrenal Medullary Autografts in Anterior Eye Chamber, Lateral Ventricle and Striatum of Adult Rats: A Long Term Study
The neurobiological basis for the short-term recovery in Parkinson's patients and experimental animals grafted with adrenal medulla is not yet clear. Structural details of the grafted chromaffin cells are also not available. In the present study, autografts of adrenal medulla in the anterior eye chamber, lateral ventricle and striatum of adult rats were studied for 360 days. Though a large numb...
متن کاملCells of the sympathoadrenal lineage: biological properties as donor tissue for cell-replacement therapies for Parkinson's disease.
Sympathoadrenal (SA) cell lineage encompasses neural crest derivatives such as sympathetic neurons, small intensely fluorescent (SIF) cells of sympathetic ganglia and adrenal medulla, and chromaffin cells of adrenal medulla and extra-adrenal paraganglia. SA autografts have been used for transplantation in Parkinson's disease (PD) for three reasons: (i) as autologous donor tissue avoids graft re...
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