Perspectives Series : Molecular Medicine in Genetically Engineered Animals Targeted Mutagenesis : Analysis of Phenotype without Germ Line Transmission

J. Clin. Invest. © The American Society for Clinical Investigation, Inc. 0021-9738/96/03/1360/06 $2.00 Volume 97, Number 6, March 1996, 1360–1365 “Molecular Medicine in Genetically Engineered Animals” Series Editor, Kenneth R. Chien January 1 Gene modification via “plug and socket” gene targeting................................. Jada Lewis, Baoli Yang, Biological insights through genomics: mouse to man ..................................... Pete Detloff, and Oliver Smithies January 15 Biological insights through genomics: mouse to man ..................................... Edward M. Rubin and Gregory S. Barsh February 1 In vitro differentiation of murine embryonic stem cells: new approaches to old problems .................................................................... Mitchell J. Weiss and Stuart H. Orkin February 15 Genes and physiology: molecular physiology in genetically engineered animals......................................................................................... Kenneth R. Chien March 1 Animal models of human disease for gene therapy........................................ James M. Wilson March 15 Targeted mutagenesis: analysis of phenotype without germ line transmission.................................................................................................... Andras Nagy and Janet Rossant April 1 Transgenesis in the rat and larger mammals.................................................. Linda Mullins and John Mullins April 15 The zebrafish: heritable diseases in transparent embryos ............................. Wolfgang Driever and Mark Fishman May 1 Recent advances in conditional gene mutation by site-directed recombination............................................................................. Jamey Marth Summary