Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members.

Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.

Tumor Cell Migration Through Tissue Microenvironments

Three-dimensional (3-D) molecular contacts, contributed by the basement membrane, ECM, and adjacent cells, provide an architectural context within which a normal cell functions. Adhesive structures are physical connections between the cytoskeleton (CSK) and the ECM (an extracellularmatrix connection) or between the CSK and the CSK of other cells (a cell-cell connection). There are several adhes...

Adhesion receptors in health and disease.

Cell adhesion molecules have been recognized to play a major role in a variety of physiological and pathological phenomena. They determine the specificity of cell-cell binding and the interactions between cells and extracellular matrix proteins. Some of them may also function as receptors that trigger intracellular pathways and participate in cellular processes like migration, proliferation, di...

Tensegrity: the architectural basis of cellular mechanotransduction.

Physical forces of gravity, hemodynamic stresses, and movement play a critical role in tissue development. Yet, little is known about how cells convert these mechanical signals into a chemical response. This review attempts to place the potential molecular mediators of mechanotransduction (e.g. stretch-sensitive ion channels, signaling molecules, cytoskeleton, integrins) within the context of t...

The winding road from adhesive receptors to the nucleus. Conference on molecular biology of cellular interactions: adhesion receptor signalling and regulation of gene expression.

Adhesive receptors are responsible for general tissue architecture and cell behaviour. They modulate mechanical adhesive interactions and regulate a cascade of intracellular signalling pathways (for reviews, see Giancotti and Ruoslahti, 1999; Gumbiner, 2000). In most cases, the end-point of the receptor-induced signalling cascade is the regulation of gene expression and corresponding modificati...