Terminating Wnt signals
نویسندگان
چکیده
Nuclear targeting of beta-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes beta-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of beta-catenin. We speculate that cells may use multiple export mechanisms to inhibit beta-catenin signaling in different ways.
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ورودعنوان ژورنال:
- The Journal of Cell Biology
دوره 171 شماره
صفحات -
تاریخ انتشار 2005