MinireviewClathrin Adaptors Really Adapt
نویسنده
چکیده
proteins into clathrin pathways. Because of their key The clathrin pathway is the principal route for receprole in linking sorted proteins with the clathrin coat, the tor-mediated endocytosis and growth factor downregassembly factors are now referred to as heterotetramulation. Heterotetrameric clathrin adaptors directly eric clathrin adaptors. link the clathrin coat with cargo transmembrane proConsiderable progress has occurred during the past teins that are sorted into coated pits and vesicles. A five years. Novel adaptors have been identified, such paper in this issue of Cell (Collins et al., 2002) describes as the heterotetrameric AP-3 and AP-4 adaptor protein the atomic structure of the adaptor-protein 2 (AP-2) complexes (which resemble AP-1 and AP-2), the monocore, the portion that makes contacts with the memmeric GGAs (Golgi-localized, -ear-containing, ARFbrane and cytosolic tails of cargo proteins. binding proteins) and members of the -arrestin family
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Clathrin Adaptors Really Adapt
The clathrin pathway is the principal route for receptor-mediated endocytosis and growth factor downregulation. Heterotetrameric clathrin adaptors directly link the clathrin coat with cargo transmembrane proteins that are sorted into coated pits and vesicles. A paper in this issue of Cell describes the atomic structure of the adaptor-protein 2 (AP-2) core, the portion that makes contacts with t...
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