Moraxella catarrhalis, a human respiratory tract pathogen.

نویسندگان

  • Timothy F Murphy
  • G Iyer Parameswaran
چکیده

Moraxella catarrhalis is an exclusively human pathogen and is a common cause of otitis media in infants and children, causing 15%-20% of acute otitis media episodes. M. catarrhalis causes an estimated 2-4 million exacerbations of chronic obstructive pulmonary disease in adults annually in the United States. M. catarrhalis resembles commensal Neisseria species in culture and, thus, may be overlooked in samples from the human respiratory tract. The prevalence of colonization of the upper respiratory tract is high in infants and children but decreases substantially in adulthood. Most strains produce beta-lactamase and are thus resistant to ampicillin but susceptible to several classes of oral antimicrobial agents. Recent work has elucidated mechanisms of pathogenesis and focused on vaccine development to prevent otitis media in children and respiratory tract infections caused by M. catarrhalis in adults with chronic obstructive pulmonary disease.

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منابع مشابه

Frequency and Risk Factors of Moraxella catarrhalis Infection in Patients at Vali-Asr and Amirkabir Hospitals since August 2003 to March 2004

Background: Moraxella catarrhalis is Gram negative diplococci which is a member of Neisseriacae. It was considered as a harmless commensal of the upper respiratory tract. Since 1990 its pathogenecity was established and known as a common cause of respiratory infection, particularly otitis media, sinusitis and lower respiratory tract. The aim of this research was to determine the prevalence and ...

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Moraxella catarrhalis, a major nasopharyngeal pathogen of the human respiratory tract, is exposed to rapid and prolonged downshifts of environmental temperature when humans breathe cold air. In the present study, we show that a 26 degrees C cold shock up-regulates the expression of UspA1, a major adhesin and putative virulence factor of M. catarrhalis, by prolonging messenger RNA half-life. Col...

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عنوان ژورنال:
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

دوره 49 1  شماره 

صفحات  -

تاریخ انتشار 2009