Screening for Fabry disease in patients with ischaemic stroke at young age: the Italian Project on Stroke in Young Adults.
نویسندگان
چکیده
L. Poli, M. Zedde, A. Zini, M. Del Sette, C. Lodigiani, A. Spalloni, F. Di Lisi, A. Toriello, V. Piras, C. Stilo, G. Tomelleri, L. Tancredi, M. Paciaroni, G. Silvestrelli, A. Adami, P. Costa, A. Morotti, V. De Giuli, F. Caria, M. Gamba, G. Malferrari, A. M. Simone, R. Musolino, E. Giorli, E. Banfi, S. Marcheselli, M. Rasura, N. Pugliese, M. Melis, P. Bovi, A. Padovani, A. Burlina*, and A. Pezzini*, On behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators Dipartimento di Scienze Cliniche e Sperimentali, Clinica Neurologica, Universit a degli Studi di Brescia, Brescia, S.C. Neurologia, Arcispedale ‘Santa Maria Nuova – IRCCS’, Reggio Emilia, Stroke Unit, Clinica Neurologica, Nuovo Ospedale Civile ‘S. Agostino Estense’, AUSL, Modena, Unit a di Neurologia, Ospedale Galliera, Genova, Centro Trombosi, IRCCS Humanitas Research Hospital, RozzanoMilano, Stroke Unit, Azienda Ospedaliera Sant’Andrea, Universit a ‘La Sapienza’, Roma, U.O.C. Neurologia, A.O. Universitaria ‘San Giovanni di Dio e Ruggi d’Aragona’, Salerno, Stroke Unit, Azienda Ospedaliera ‘G. Brotzu’, Cagliari, Dipartimento di Neuroscienze, Scienze Psichiatriche e Anestesiologiche, Clinica Neurologica, Universit a di Messina, Messina, UO Neurologia, Azienda Ospedaliera-Universitaria Borgo Trento, Verona, U.O. Neurologia, ASST Lariana – Ospedale Sant’Anna, Como, Stroke Unit, Divisione di Medicina Cardiovascolare, Universit a di Perugia, Perugia, Stroke Unit, Dipartimento di Neuroscienze, Azienda Ospedaliera Carlo Poma, Mantova, Stroke Center, Dipartimento di Neurologia, Ospedale Sacro Cuore Negrar, Verona, Stroke Unit, Neurologia Vascolare, Spedali Civili di Brescia, Brescia, Unit a di Neurologia, Ospedale S. Andrea, La Spezia, Neurologia d’Urgenza and Stroke Unit, IRCCS Humanitas Research Hospital, RozzanoMilano, and Neurologia, Dipartimento di Medicina Interna, Ospedale San Bassiano, Bassano del Grappa, Italy
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ABSTRACT Among all the neurologic diseases of adult life, the cerebrovascular accident (CVA) clearly rank, first in terms of frequency and importance. Contrary to a common view, stroke in the age range of 15 to 45, is not rare. Stroke can be particularly dramatic when a young, previously healthy individual experiences acute cerebral infarction. Apart from the early dramatic consequences of st...
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BACKGROUND AND PURPOSE Fabry disease is an X-linked monogenic disorder caused by mutations in the GLA gene. Recent data suggest that stroke in young adults may be associated with Fabry disease. We aimed to ascertain the prevalence of this disorder among young adult patients with stroke in Portugal by GLA genotyping. METHODS During 1 year, all patients aged 18 to 55 years with first-ever strok...
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Fabry disease (FD) is a rare hereditary lysosomal storage disease that has been highlighted as a possible etiology of stroke at a young age. The prevalence of ischemic stroke has been reported to be about 12 times greater in FD patients than that expected in a comparable general population. Cerebrovascular events in males typically occur at an early age and preferentially within the territory o...
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BACKGROUND Stroke is a leading cause of death and disability in developing countries, afflicting individuals at a young age. The contribution of established vascular risk factors to ischaemic stroke in young adults has not been evaluated systematically in Indians. METHODS We conducted a case control study in 214 South Indian patients with first acute ischaemic stroke that occurred between the...
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ورودعنوان ژورنال:
- European journal of neurology
دوره 24 3 شماره
صفحات -
تاریخ انتشار 2017