Protein Folding as a Random Walk
نویسنده
چکیده
Large numbers of native-fitting and random-coil conformations of a small protein, pancreatic trypsin inhibitor, have been generated as self-avoiding random walks on a face-centred cubic lattice. Randomcoil conformations similar to the native X-ray conformation occur frequently enough to suggest that well-defined kinetic pathways for protein folding are not as necessary as is usually thought.
منابع مشابه
PROTEIN FOLDING AS A RANDOM WALK bY
Large numbers of native-fitting and random-coil conformations of a small protein, pancreatic trypsin inhibitor, have been generated as self-avoiding random walks on a face-centred cubic lattice. Randomcoil conformations similar to the native X-ray conformation occur frequently enough to suggest that well-defined kinetic pathways for protein folding are not as necessary as is usually thought.
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