In Silico Mutational Analysis and Drug Interaction Studies of HIV Reverse Transcriptase
نویسندگان
چکیده
Human immunodeficiency virus is a retrovirus that causes acquired immunodeficiency syndrome, a condition in humans in which the immune system begins to fail, leading to life threatening opportunistic infections. Reverse transcriptase inhibitors are class of antiretroviral drugs used to treat HIV infection. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase enzyme that HIV needs to replace. Protein P04585|POL_HV1H2 Gag-Pol polyprotein Human immunodeficiency virus type 1 (isolate HXB2 group M subtype B) (HIV-1) was docked with RTIs and thebfree energies of the docking complexes were analyzed. It was concluded that M184V mutations has least impact than that of other mutations and Y115F
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