Resveratrol inhibits the TRIF dependent pathway by up-regulating SARM,
نویسندگان
چکیده
1 contributing to anti-inflammatory effects after respiratory syncytial virus 2 infection 3 Running title: SARM regulated IFN-γ after RSV infection 4 Tiantian Liu , Na Zang, Na Zhou, Wei Li, Xiaohong Xie, Yu Deng, Luo Ren, 5 Xiaoru Long , Simin Li, Lili Zhou, Xiaodong Zhao, Wenwei Tu, Lijia Wang, 6 Bin Tan , Enmei Liu. 7 1 Ministry of Education Key Laboratory of Child Development and Disorders; Key 8 Laboratory of Pediatrics in Chongqing , CSTC2009CA5002; Chongqing 9 International Science and Technology Cooperation Center for Child Development 10 and Disorders, Chongqing Medical University, Chongqing 400014, China; 11 Department of Respiratory Medicine, Children's Hospital of Chongqing Medical 12 University, Chongqing, China. 13 3 Department of Immunology, Children's Hospital of Chongqing Medical University, 14 Chongqing, China. 15 Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of 16 Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China. 17 *These authors contributed equally to this work. 18 # Corresponding author. Mailing address: Department of Respiratory Medicine, 19 Children's Hospital of Chongqing Medical University, Chongqing, China, No.136, 20 Zhongshan 2nd Road, Yuzhong District, Chongqing, 400014, China, Telephone: 21 JVI Accepts, published online ahead of print on 29 January 2014 J. Virol. doi:10.1128/JVI.03637-13 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
منابع مشابه
MMP-12-mediated by SARM-TRIF signaling pathway contributes to IFN-γ-independent airway inflammation and AHR post RSV infection in nude mice
BACKGROUND Respiratory syncytial virus (RSV) is one of the most frequently observed pathogens during infancy and childhood. However, the corresponding pathogenesis has not been determined to date. We previously demonstrated that IFN-γ plays an important role in RSV pathogenesis, and SARM-TRIF-signaling pathway could regulate the production of IFN-γ. This study is to investigate whether T cells ...
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