Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+ -adenosine triphosphatase in ethanol treated Wistar rats.

نویسندگان

  • Maneesh Mailankot
  • H Jayalekshmi
  • Amit Chakrabarti
  • Neha Alang
  • D M Vasudevan
چکیده

Ethanol intoxication resulted in high extent of lipid peroxidation, and reduction in antioxidant defenses (decreased GSH, GSH/GSSG ratio, and catalase, SOD and GPx activities) and (Na+/K+)-ATPase activity in kidney. Alpha-tocopherol treatment effectively protected kidney from ethanol induced oxidative challenge and improved renal (Na+/K+)-ATPase activity. Ethanol induced oxidative stress in the kidney and decreased (Na+/K+)-ATPase activity could be reversed by treatment with ascorbic acid.

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عنوان ژورنال:
  • Indian journal of experimental biology

دوره 47 7  شماره 

صفحات  -

تاریخ انتشار 2009