Gels of Normal and Sickled Hemoglobin Comparative Study
نویسنده
چکیده
The specific defect in molecules of sickle hemoglobin (HbS) has been known for many years (1), but the nature of the assembled polymers of HbS which distort susceptible erythrocytes remains unclear. Several structural forms of sickled hemoglobin have been observed in electron microscopic studies, including a mat-like arrangement of fibers (2), empty hexagonal crystals (3), microtubules (4), and dense rods (5, 6). I t is unlikely that the process of sickling results in formation of all of the different structural arrangements described by various workers.
منابع مشابه
Gels of Normal and Sickled Hemoglobin
Electron microscopic studies of the sickling phenomenon have described at least three different structural arrangements of sickled hemoglobin, including empty hexagonal crystals, microtubules, and solid rods. It is unlikely that sickling results in several different polymers, and it is essential to determine the true structure of sickled hemoglobin in order to define the mechanism of molecular ...
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E CRUMPLING of disc-shaped erythrocytes into bizarre forms is considered the basic pathological feature of sickle cell anemia.1 Several investigators have established that erythrocyte sickling is due to intracellular precipitation of deoxygenated sickle hemoglobin ( Hb S ).2.T A recent ultrastructural study by Murayarna identified the presence of tubular rods of Hb S in whole mount preparations...
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