Toll-Like Receptor 2-Dependent NF- B Activation Is Involved in Nontypeable Haemophilus influenzae-Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear
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چکیده
Toll-Like Receptor 2-Dependent NFB Activation Is Involved in Nontypeable Haemophilus influenzae-Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear Sung K. Moon, Jeong-Im Woo, Haa-Yung Lee, Raekil Park,† Jun Shimada,‡ Huiqi Pan, Robert Gellibolian, and David J. Lim* The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California, and Department of Otolaryngology and Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California
منابع مشابه
ERK2-dependent activation of c-Jun is required for nontypeable Haemophilus influenzae-induced CXCL2 upregulation in inner ear fibrocytes.
The inner ear, composed of the cochlea and the vestibule, is a specialized sensory organ for hearing and balance. Although the inner ear has been known as an immune-privileged organ, there is emerging evidence indicating an active immune reaction of the inner ear. Inner ear inflammation can be induced by the entry of proinflammatory molecules derived from middle ear infection. Because middle ea...
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BACKGROUND Otitis media (OM), one of the most common pediatric infectious diseases, causes inner ear inflammation resulting in vertigo and sensorineural hearing loss. Previously, we showed that spiral ligament fibrocytes (SLFs) recognize OM pathogens and up-regulate chemokines. Here, we aim to determine a key molecule derived from SLFs, contributing to OM-induced inner ear inflammation. METHO...
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