Treatment efficacy in a soman poisoned guinea
نویسندگان
چکیده
منابع مشابه
The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice.
AIM The ability of four newly prepared reversible inhibitors of acetylcholinesterase (6-chlorotacrine, 7-phenoxytacrine, compounds 1 and 2) and currently used carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was evaluated. METHODS The evaluation of the effect of pharmacological pretreatment is based on the...
متن کاملA comparison of protective and anticonvulsive efficacy of two prophylactic mixtures in soman-poisoned rats
The protective and anticonvulsive efficacy of two prophylactic mixtures (PANPAL consisting of pyridostigmine, benactyzine, and trihexyphenidyle and pyridostigmine plus biperiden) administered prior to the administration of soman in a lethal dose (1.5 LD50) with or without antidotal treatment (atropine + HI-6) was evaluated using rats as experimental animals. The pretreatment was applied 30 and ...
متن کاملTenocyclidine treatment in soman-poisoned rats--intriguing results on genotoxicity versus protection.
This study aimed to evaluate the antidotal potency of tenocyclidine (TCP) that probably might protect acetylcholinesterase (AChE) in the case of organophosphate poisoning. TCP was tested alone as a pretreatment or in combination with atropine as a therapy in rats poisoned with (1/4) and (1/2) of LD(50) of soman. Possible genotoxic effects of TCP in white blood cells and brain tissue were also s...
متن کاملProtective efficacy of catalytic bioscavenger, paraoxonase 1 against sarin and soman exposure in guinea pigs.
Human paraoxonase 1 (PON1) has been portrayed as a catalytic bioscavenger which can hydrolyze large amounts of chemical warfare nerve agents (CWNAs) and organophosphate (OP) pesticides compared to the stoichiometric bioscavengers such as butyrylcholinesterase. We evaluated the protective efficacy of purified human and rabbit serum PON1 against nerve agents sarin and soman in guinea pigs. Cataly...
متن کاملThe Efficacy of the Czech Original Prophylactic Mixture, Called Panpal, as Pharmacological Pretreatment of Tabun or Soman-poisoned Rats and Mice
The potency of the Czech original pharmacological pretreatment consisting of pyridostigmine, benactyzine and trihexyphenidyle, designated PANPAL, to increase the resistance of rats and mice against tabun or soman and to increase the therapeutic efficacy of standard antidotal treatment of tabun or soman-poisoned experimental animals was studied and compared with commonly used pyridostigmine alon...
متن کامل