Rasgrp4-dependent Arthritis and Proliferation of Fls
نویسندگان
چکیده
Michihito Kono, MD, Shinsuke Yasuda, MD, PhD, Hideyuki Koide, Takashi Kurita, MD, Yuka Shimizu, MD, Yusaku Kanetsuka, MD, Kenji Oku, MD, PhD, Toshiyuki Bohgaki, MD, PhD, Olga Amengual, MD, PhD, Tetsuya Horita, MD, PhD, Takao Koike, MD, PhD, and Tatsuya Atsumi, MD, PhD: Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; Richard L Stevens, PhD: Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA; Tomohiro Shimizu, MD: Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan; Tokifumi Majima, MD, PhD: Department of Joint Replacement and Tissue Engineering, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
منابع مشابه
Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic autoimmune disease with high morbidity and mortality. Within the inflammatory milieu, resident fibroblast-like synoviocytes (FLS) in the synovial tissue undergo hyperplasia, which leads to joint destruction. Epidemiologic studies and our previous research suggest that activation of the aryl hydrocarbon receptor (AHR) pathway plays an instrumental role in t...
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