Interactions with Apoptotic Cells as well as Vitronectin Inhibits Efferocytosis through
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Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages.
Effective removal of apoptotic cells, particularly apoptotic neutrophils, is essential for the successful resolution of acute inflammatory conditions. In these experiments, we found that whereas interaction between vitronectin and integrins diminished the ability of macrophages to ingest apoptotic cells, interaction between vitronectin with urokinase-type plasminogen activator receptor (uPAR) o...
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Friggeri A, Yang Y, Banerjee S, Park Y, Liu G, Abraham E. HMGB1 inhibits macrophage activity in efferocytosis through binding to the v 3-integrin. Am J Physiol Cell Physiol 299: C1267–C1276, 2010. First published September 8, 2010; doi:10.1152/ajpcell.00152.2010.— Phagocytosis of apoptotic cells is critical to resolution of inflammation. High mobility group box 1 protein (HMGB1), a mediator of ...
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Macrophages play a key role in atherosclerotic plaque formation and rupture. These phagocytic cells are important in the scavenging of modified lipoproteins, unwanted or dead cells and cellular debris through efferocytosis. Sirtuin1 (Sirt1), a member of the conserved sirtuin family and a key regulator in the progression of atherosclerosis exerts protective effects by regulating autophagy, a wel...
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For opportunistic pathogens such as Pseudomonas aeruginosa, the mucosal barrier represents a formidable challenge. Infections develop only in patients with altered epithelial barriers. Here, we showed that P. aeruginosa interacts with a polarized epithelium, adhering almost exclusively at sites of multi-cellular junctions. In these sites, numerous bacteria attach to an extruded apoptotic cell o...
متن کاملERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis.
BACKGROUND Efferocytosis is a process by which dead and dying cells are removed by phagocytic cells. Efferocytosis by macrophages is thought to curb the progression of atherosclerosis, but the mechanistic insight of this process is lacking. METHODS AND RESULTS When macrophages were fed apoptotic cells or treated with pitavastatin in vitro, efferocytosis-related signaling and phagocytic capaci...
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