pH-regulated asymmetric transfer hydrogenation of quinolines in water.
نویسندگان
چکیده
1,2,3,4-Tetrahydroquinolines exist as key structural elements in many natural products and have found broad commercial application. In particular, optically pure tetrahydroquinolines are commonly present in alkaloids and are required in pharmaceutical and agrochemical synthesis. Representative examples include the bioactive alkaloids (+)-galipinine and ( )-augustureine, and the antibacterial drug (S)-flumequine.
منابع مشابه
Highly enantioselective transfer hydrogenation of quinolines catalyzed by gold phosphates: achiral ligand tuning and chiral-anion control of stereoselectivity.
A little gold goes a long way: as little as 0.01 mol % of chiral gold phosphate is sufficient to afford the asymmetric transfer hydrogenation of quinolines with high stereoselectivity (up to 98 % ee). The achiral ligands on gold were found to have considerable effect on the catalytic efficiency.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 48 35 شماره
صفحات -
تاریخ انتشار 2009