Nonexcitatory electrical signals for enhancing ventricular contractility: rationale and initial investigations of an experimental treatment for heart failure.
نویسندگان
چکیده
[PDF] [Full Text] [Abstract] , April 2, 2008; 29 (8): 1019-1028. Eur. Heart J. Frigerio, M. Parides, D. Burkhoff and G. Hindricks Curnis, D. Bocker, A. Remppis, J. Kautzner, M. Stuhlinger, C. Leclerq, M. Taborsky, M. M. M. Borggrefe, T. Lawo, C. Butter, H. Schmidinger, M. Lunati, B. Pieske, A. R. Misier, A. electrical impulses for symptomatic heart failure Randomized, double blind study of non-excitatory, cardiac contractility modulation [PDF] [Full Text] , April 2, 2008; 29 (8): 961-963. Eur. Heart J. J. C. Daubert Modulation of cardiac contractility. A potential treatment of heart failure? [PDF] [Full Text] [Abstract] , May 6, 2008; 51 (18): 1784-1789. J. Am. Coll. Cardiol. C. Butter, S. Rastogi, H.-H. Minden, J. Meyhofer, D. Burkhoff and H. N. Sabbah in Patients With Heart Failure Cardiac Contractility Modulation Electrical Signals Improve Myocardial Gene Expression [PDF] [Full Text] [Abstract] , December 1, 2008; 10 (12): 1375-1380. Europace H. Nagele, S. Behrens and C. Eisermann Cardiac contractility modulation in non-responders to cardiac resynchronization therapy [PDF] [Full Text] [Abstract] , December 1, 2009; 2 (12): 1341-1349. J. Am. Coll. Cardiol. Img. and J. W.-H. Fung C.-M. Yu, J. Y.-S. Chan, Q. Zhang, G. W.K. Yip, Y.-Y. Lam, A. Chan, D. Burkhoff, P.-W. Lee Function and Remodeling Impact of Cardiac Contractility Modulation on Left Ventricular Global and Regional
منابع مشابه
A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation in patients with systolic heart failure: rationale, design, and baseline patient characteristics.
Cardiac contractility modulation (CCM) signals are nonexcitatory electrical signals delivered during the cardiac absolute refractory period that enhance the strength of cardiac muscular contraction. Prior research in experimental and human heart failure has shown that CCM signals normalize phosphorylation of key proteins and expression of genes coding for proteins involved in regulation of calc...
متن کاملChronic electrical stimulation during the absolute refractory period of the myocardium improves severe heart failure.
AIM In experimental studies, nonexcitatory electrical stimulation delivered at the time of absolute myocardial refractoriness resulted in cardiac contractility modulation (CCM) with improved systolic function. This study reports the initial experience with CCM in patients with chronic heart failure. METHODS AND RESULTS Twenty-five patients, 23 males, with a mean age of 62+/-9 years and drug-r...
متن کاملDoes contractility modulation have a role in the treatment of heart failure?
Cardiac resynchronization therapy (CRT) is an established therapy for patients with systolic dysfunction, QRS duration greater than 120 ms, and New York Heart Association (NYHA) class III or IV symptoms. However, most patients with heart failure have QRS duration below 120 ms and 30% or more of CRT recipients are nonresponders. Cardiac contractility modulation (CCM) signals are nonexcitatory el...
متن کاملFirst Human Chronic Experience with Cardiac Contractility Modulation by Nonexcitatory Electrical Currents for Treating Systolic Heart Failure:
Electrical Modulation of the Failing Contractility. Introduction: Conventional electrical therapies for heart failure (HF) encompass defibrillation and ventricular resynchronization for patients at high risk for lethal arrhythmias and/or with inhomogeneous ventricular contraction. Cardiac contractility modulation (CCM) by means of nonexcitatory electrical currents delivered during the action po...
متن کاملA randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation in patients with moderately reduced left ventricular ejection fraction and a narrow QRS duration: study rationale and design.
Cardiac contractility modulation (CCM) signals are nonexcitatory electrical signals delivered during the cardiac absolute refractory period that enhance the strength of cardiac muscular contraction. The FIX-HF-5 study was a prospective randomized study comparing CCM plus optimal medical therapy (OMT) to OMT alone that included 428 New York Heart Association (NYHA) functional class III or IV hea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- American journal of physiology. Heart and circulatory physiology
دوره 288 6 شماره
صفحات -
تاریخ انتشار 2005