Dynamics of Genetic Information: Fundamental Basis and Cancer

Teams in this unit aim at elucidating the regulation of mechanisms that are crucial to the maintenance of genome integrity, like DNA replication, repair and recombination, as well as the role of cell cycle checkpoints and non-coding RNAs in genome and epigenome maintenance. Experimental models include yeast, mammalian and human cell lines, mutant mouse models and tumour samples. A large variety of methods is used including genetic, molecular and cytogenetic techniques, fluorescence in situ hybridisation and DNA 'combing', as well as high throughput sequencing approaches such as DNA-seq for mutation landscape analyses, RNA-seq for transcrip-tome analyses and ChIP-seq mapping of chromatin-associated proteins and their genome-wide modulation in response to DNA damages.