Differential effects of isoproterenol on the canine atrial action potential in the presence of carbachol or nicorandil.
نویسندگان
چکیده
In canine atrial muscles, carbachol and nicorandil hyperpolarized the resting membrane potential and shortened the action potential duration. In the presence of carbachol or nicorandil, isoproterenol further hyperpolarized the resting membrane potential and shortened the action potential duration. Isoproterenol significantly increased the plateau duration in the presence of nicorandil, but further abbreviated it in the presence of carbachol. This increase in the plateau duration by isoproterenol in the presence of nicorandil probably reflects the increase in the slow inward current.
منابع مشابه
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ورودعنوان ژورنال:
- Japanese journal of pharmacology
دوره 44 2 شماره
صفحات -
تاریخ انتشار 1987