Fatty livers induced by orotic acid. II. Changes in nucleotide metabolism.
نویسندگان
چکیده
Rats fed a purified diet supplemented with erotic acid (1%) have gross alterations in their lipid metabolism that can be essentially nullified by further supplementation of the diet with adenine sulfate (0.25%), as described in the first paper of this series (1). Accompanying these changes are certain alterations in the metabolism of pyrimidine derivatives, which have been described in an earlier report (2). Other reports of alterations in the pools of pyrimidine nucleotides in animals fed erotic acid have appeared in preliminary form (3). Hurlbert and Potter (4) have studied the fate of tracer doses of orotate-6-C14 with emphasis on its role as a precursor of the pyrimidine-containing components of nucleic acids. The present report’ presents an analysis of the fate of dietary erotic acid and the levels of purine and pyrimidine nucleotides in the livers of rats fed various supplemented diets, as well as studies of the formation of nucleotides and the catabolism of orotate in liver slices and cell-free extracts.
منابع مشابه
An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.
In functional genomics, DNA microarrays for gene expression profiling are increasingly being used to provide insights into biological function or pathology. To better understand the significance of the multiple transcriptional changes across a time period, the temporal changes in phenotype must be described. Orotic acid-induced fatty liver disease was investigated at the transcriptional and met...
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1. The metabolism of 4-[4-14C]androstene-3,17-dione, 4-[4-14C]pregnene-3,20-dione, 5a-[4-14C]androstane-3a,17f8-diol, [4-4C]cholesterol, 7a-hydroxy4-6fi-3H]cholesten3-one, 5fi-[7fi-3H]cholestane-3a,7U-diol and [3H]lithocholic acid was studied in the microsomal fraction of livers from control and orotic acid-treated male rats. 2. As a result of the treatment the orotic acid-fed rats had fatty li...
متن کاملFatty Livers Induced by Orotic Acid
Rats fed a purified diet supplemented with erotic acid (1%) have gross alterations in their lipid metabolism that can be essentially nullified by further supplementation of the diet with adenine sulfate (0.25%), as described in the first paper of this series (1). Accompanying these changes are certain alterations in the metabolism of pyrimidine derivatives, which have been described in an earli...
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The present study was conducted to elucidate the metabolic pathways by which enlarged liver size of patients undergoing disorders of orotic acid de novo metabolism and those patients of enlarged liver size induced by di(2-ethyl hexyl) phthalate in rats as animal model. The results showed that rats-treated with orotic acid generated liver triglyceride content 400% higher than that of the control...
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 238 شماره
صفحات -
تاریخ انتشار 1963