Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.

نویسندگان

  • V C Kalfa
  • H P Jia
  • R A Kunkle
  • P B McCray
  • B F Tack
  • K A Brogden
چکیده

SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosa PAO1.

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The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 45 11  شماره 

صفحات  -

تاریخ انتشار 2001