Evaluation of Type 1 Immune Response in Naïve and Vaccinated Animals following Challenge with Leptospira borgpetersenii Serovar Hardjo: Involvement of WC1 and CD4 T Cells
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چکیده
Evaluation of Type 1 Immune Response in Naïve and Vaccinated Animals following Challenge with Leptospira borgpetersenii Serovar Hardjo: Involvement of WC1 and CD4 T Cells Brian M. Naiman, Seth Blumerman, David Alt, Carole A. Bolin, Rachel Brown, Richard Zuerner, and Cynthia L. Baldwin* Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003; Bacterial Diseases of Livestock Research Unit, U.S. Department of Agriculture, National Animal Disease Center, Ames, Iowa 50010; and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan 48824
منابع مشابه
Efficacy of vaccination of cattle with the Leptospira interrogans serovar hardjo type hardjoprajitno component of a pentavalent Leptospira bacterin against experimental challenge with Leptospira borgpetersenii serovar hardjo type hardjo-bovis.
OBJECTIVE To evaluate the efficacy of vaccination with the Leptospira interrogans serovar hardjo type hardjoprajitno component of a pentavalent Leptospira bacterin against a virulent experimental challenge with Leptospira borgpetersenii serovar hardjo type hardjo-bovis strain 203 in cattle. ANIMALS Fifty-five 6-month-old Holstein heifers. PROCEDURES Heifers that were negative for persistent...
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Most epidemiologic studies on bovine leptospirosis are based on serological tests that use antibodies against several serotypes, including the serovar Hardjo, which is widespread and considered to be the most adapted to bovine hosts. However, using only serological studies is not sufficient to identify and distinguish species of leptospires. The aim of this study was report the first isolation ...
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OBJECTIVE To determine whether vaccination with a monovalent vaccine against Leptospira borgpetersenii serovar Hardjo strain hardjobovis would improve reproductive efficiency in Holstein cattle in a commercial dairy setting. DESIGN Randomized controlled trial. ANIMALS 1,894 Holstein cows and heifers from a Central California dairy. PROCEDURES Cattle were assigned to undergo SC administrat...
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The genome of a laboratory-adapted strain of Leptospira interrogans serovar Hardjo was sequenced and analyzed. Comparison of the sequenced genome with that recently published for a field isolate of the same serovar revealed relatively high sequence conservation at the nucleotide level, despite the different biological background of both samples. Conversely, comparison of both serovar Hardjo gen...
متن کاملWC1 is a hybrid γδ TCR coreceptor and pattern recognition receptor for pathogenic bacteria.
WC1 proteins are uniquely expressed on γδ T cells and belong to the scavenger receptor cysteine-rich (SRCR) superfamily. While present in variable, and sometimes high, numbers in the genomes of mammals and birds, in cattle there are 13 distinct genes (WC1-1 to WC1-13). All bovine WC1 proteins can serve as coreceptors for the TCR in a tyrosine phosphorylation dependent manner, and some are requi...
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