Correction: H. pylori CagL-Y58/E59 Prime Higher Integrin α5β1 in Adverse pH Condition to Enhance Hypochlorhydria Vicious Cycle for Gastric Carcinogenesis
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چکیده
The authors have provided DNA sequencing and RT-PCR data in supporting information files: Figure S1 shows a diagram of the construction of the cagL mutant (A), revertant, and amino acid replacement mutants (B). Figure S2 confirms the cagL mutant, revertant, and amino acid replacement mutants using PCR. Figure S3 shows sequencing results of H. pylori clinical strain Hp1033 wild type, cagL insertion mutant, revertant, and amino acid replacement mutants. Figure S4 shows RT-PCR of cagL expression for Hp1033 wild type, cagL mutant and replacement mutants co-cultured with AGS cells at pH 7.4 for 1 hour. Table S1 shows the primers used for sequencing and RT-PCR. The authors have no Anti-CagL antibody, and so they are not able to show protein expression. Sharing of the strains/isolates of H. pylori reported in the manuscript may be done following a formal request. This application is necessary to comply with the regulatory processes in the authors’ institution and the customs/export regulations between Taiwan and other countries.
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Correction: Correction: H. pylori CagL-Y58/E59 Prime Higher Integrin α5β1 in Adverse pH Condition to Enhance Hypochlorhydria Vicious Cycle for Gastric Carcinogenesis
BACKGROUND/AIMS H. pylori CagL amino acid polymorphisms such as Y58/E59 can increase integrin α5β1 expression and gastric cancer risk. Hypochlorhydria during chronic H. pylori infection promotes gastric carcinogenesis. The study test whether CagL-Y58/E59 isolates may regulate integrin α5β1 to translocate CagA via the type IV secretory system even under adverse pH conditions, and whether the int...
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