Lucey-Driscoll syndrome Secretion of Dubin-Johnson syndrome

نویسنده

  • ROGER WILLIAMS
چکیده

Cholestasis may be defined as stagnation of bile within the intrahepatic or extrahepatic biliary tree. Biochemically, there is retention of conjugated bilirubin, bile salts, and alkaline phosphatase; morphologically, there is at least dilatation of biliary canaliculi and loss of their microvilli, and later accumulation of bile pigment in the canaliculi (bile plugs)."0 The mechanism underlying the canalicular lesion is unknown," though a variety of hepatic diseases may cause it. Similar cholestasis has been produced by the administration of some bile salts, such as lithocholates, which are relatively insoluble and may precipitate in the canaliculi; hence qualitative changes in the metabolism of the bile acids could be important.12

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تاریخ انتشار 2006