Flowsheet Modeling of a Continuous Direct Compression Tableting Process at Production Scale
نویسندگان
چکیده
A flowsheet model for a continuous direct compression tableting process is developed and applied to process data. The model contains powder feeding, blending and tablet compaction unit operations. The dataset was provided by Merck & Co., Inc., Kenilworth, NJ USA using a GEA ConsiGma continuous direct compression process designed for a 50 kg/h throughput using a six ingredient, potentially commercial, formulation. A tanks-in-series methodology is used to model the transport of powder through the blending units and the tablet press model allows upstream changes in composition to be propagated to the tablet properties. The flowsheet model performed well based on the available dataset and will be used for further process optimization as the process approaches commercial production.
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