Management of drug overdoses.

Poisonings and overdoses in the intensive care unit: general and specific management issues.

OBJECTIVE To provide current information on general and specific interventions for overdoses likely to require intensive care. DESIGN Review of literature relevant to selected interventions for general management of overdoses and specific poisons. RESULTS The benefit of interventions to decrease absorption or enhance elimination of toxins is limited to a relatively small number of specific ...

Massive overdoses with sustained-release lithium carbonate preparations: pharmacokinetic model based on two case studies.

Clinically significant delayed absorption after lithium overdose has been reported previously without adequate explanation. We have studied two patients after they took massive intentional lithium overdoses. The first patient presented shortly after ingesting 74 g of lithium carbonate. Pharmacokinetic analysis with a multicompartmental model of 29 serum lithium concentrations during 300 h (incl...

Circumstances surrounding non‐fatal opioid overdoses attended by ambulance services

INTRODUCTION AND AIMS Opioid overdose fatalities are a significant concern globally. Non-fatal overdoses have been described as a strong predictor for future overdoses, and are often attended by the ambulance services. This paper explores characteristics associated with non-fatal overdoses and aims to identify possible trends among these events in an urban area in Norway. DESIGN AND METHODS T...

Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature

Calcium channel antagonists (CCAs) are commonly involved in drug overdoses. Standard approaches to the management of CCA overdoses, including fluid resuscitation, gut decontamination, administration of calcium, glucagon, and atropine, as well as supportive care, are often ineffective. We report on two patients who improved after addition of hyperinsulinemia-euglycemia (HIE) therapy. We conclude...

Management considerations following overdoses of modified-release morphine preparations