Late potentials and the Brugada syndrome.

نویسنده

  • Charles Antzelevitch
چکیده

The Brugada syndrome accounts for approximately 20% of cases of sudden cardiac death in patients with structurally normal hearts (1–3). The syndrome is characterized by an ST-segment elevation in right precordial leads (V1 to V3) unrelated to ischemia, electrolyte disturbances or obvious structural heart disease, and is sometimes accompanied by a right bundle branch block (RBBB) morphology of the QRS. This electrocardiographic (ECG) signature was reported as early as 1953, but it was first described as a distinct clinical entity associated with a high risk of sudden cardiac death by Pedro and Josep Brugada in 1992 (4). These characteristics of the Brugada syndrome are similar to those reported by Nademanee et al. (5) for patients with sudden unexplained death syndrome, and recent study has advanced data suggesting the two syndromes are genetically and functionally the same disorder (6).

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Human ventricular action potential duration restitution.

. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden death: a distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992;20:1391–6. . Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 1999;100:1660–6. . Breithardt G, Cain ME, El-Sheri...

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Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome

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عنوان ژورنال:
  • Journal of the American College of Cardiology

دوره 39 12  شماره 

صفحات  -

تاریخ انتشار 2002