-Conotoxin PIA Is Selective for 6 Subunit-Containing Nicotinic Acetylcholine Receptors
نویسندگان
چکیده
Cheryl Dowell,1 Baldomero M. Olivera,1 James E. Garrett,4 Sarah T. Staheli,1 Maren Watkins,2 Alexander Kuryatov,5 Doju Yoshikami,1 Jon M. Lindstrom,5 and J. Michael McIntosh1,3 Departments of 1Biology, 2Pathology, and 3Psychiatry, University of Utah, Salt Lake City, Utah 84112, 4Cognetix, Salt Lake City, Utah 84108, and 5Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104
منابع مشابه
Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras.
Heterologous expression systems have increased the feasibility of developing selective ligands to target nicotinic acetylcholine receptor (nAChR) subtypes. However, the alpha6 subunit, a component in nAChRs that mediates some of the reinforcing effects of nicotine, is not easily expressed in systems such as the Xenopus oocyte. Certain aspects of alpha6-containing receptor pharmacology have been...
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Activation of presynaptic nicotinic acetylcholine receptors (nAChRs) can induce the release of neurotransmitters such as dopamine and norepinephrine in the CNS. Accumulating evidence suggests that distinct nAChR subtypes are involved; however, it has been difficult to determine the subunit composition of these receptors, in part because of the lack of a sufficient variety of selective nAChR lig...
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Nicotine's modulation of hippocampal noradrenergic neurotransmission may contribute to its mnemonic properties, but the nicotinic acetylcholine receptor (nAChR) subtypes that modulate terminal release of norepinephrine are unknown. In the present study, we used a number of subtype-selective alpha-conotoxins in combination with nicotinic receptor subunit-deficient mice to characterize nAChRs tha...
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