PHARMACOLOGY AND TOXICOLOGY Opinion
نویسنده
چکیده
Citation: Leslie C Sharkey and Beshay N Zordoky. “Sexual Dimorphism of Doxorubicin-Induced Cardiotoxicity”. EC Pharmacology and Toxicology 1.S1 (2015): S4-S6. Doxorubicin is a potent chemotherapeutic agent widely used to treat both hematologic malignancies and solid tumours in paediatric and adult cancer patients. Unfortunately, the clinical utility of this effective agent is limited by dose-dependent cardiotoxicity that may progress to cardiac dysfunction and heart failure. Even after 40 years of preclinical and clinical research, the exact mechanism of doxorubicin-induced cardiotoxicity is not completely understood. Similarly, the best prevention and/or treatment strategy to mitigate cardiotoxicity has not been identified yet [1]. Nevertheless, there are several factors that have been demonstrated to increase the risk of doxorubicin-induced cardiotoxicity including: total cumulative dose, pre-existing cardiovascular disease, and administration of other cardiotoxic chemotherapeutic agents such as trastuzumab [2]. However, there is inconclusive evidence about the role of sex as a risk factor of doxorubicin-induced cardiotoxicity.
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