Riemannian tangent space mapping and elastic net regularization for cost-effective EEG markers of brain atrophy in Alzheimer's disease
نویسندگان
چکیده
The diagnosis of Alzheimer’s disease (AD) in routine clinical practice is most commonly based on subjective clinical interpretations. Quantitative electroencephalography (QEEG) measures have been shown to reflect neurodegenerative processes in AD and might qualify as affordable and thereby widely available markers to facilitate the objectivization of AD assessment. Here, we present a novel framework combining Riemannian tangent space mapping and elastic net regression for the development of brain atrophy markers. While most AD QEEG studies are based on small sample sizes and psychological test scores as outcome measures, here we train and test our models using data of one of the largest prospective EEG AD trials ever conducted, including MRI biomarkers of brain atrophy.
منابع مشابه
Adaptive Error Detection Method for P300-based Spelling Using Riemannian Geometry
Brain-Computer Interface (BCI) systems have become one of the valuable research area of ML (Machine Learning) and AI based techniques have brought significant change in traditional diagnostic systems of medical diagnosis. Specially; Electroencephalogram (EEG), which is measured electrical activity of the brain and ionic current in neurons is result of these activities. A brain-computer interfac...
متن کاملA Geometry Preserving Kernel over Riemannian Manifolds
Abstract- Kernel trick and projection to tangent spaces are two choices for linearizing the data points lying on Riemannian manifolds. These approaches are used to provide the prerequisites for applying standard machine learning methods on Riemannian manifolds. Classical kernels implicitly project data to high dimensional feature space without considering the intrinsic geometry of data points. ...
متن کاملHippocampal Atrophy Studying in Alzheimer's Disease Diagnosis Using Brain MRI Images
Background and Aim: For effective treatment of Alzheimer's disease (AD), it is important to accurately diagnosis of AD and its earlier stage, Mild Cognitive Impairment (MCI). One of the most important approaches of early detection of AD is to measure atrophy, which uses various kinds of brain scans, such as MRI. The main objective of the current research was to provide a computerized diagnostic...
متن کاملThe role of genetics in alzheimer’s disease
Alzheimer's disease is a progressive neurological disorder that causes the brain to shrink (atrophy) and brain cells die. Alzheimer's disease is the most common cause of dementia and causes a decrease in thinking skills and social behaviors. Alzheimer's disease is more common in people over 65 years old. The risk of developing Alzheimer's disease and other types of dementia increases with age,...
متن کاملIdentification of Riemannian foliations on the tangent bundle via SODE structure
The geometry of a system of second order differential equations is the geometry of a semispray, which is a globally defined vector field on TM. The metrizability of a given semispray is of special importance. In this paper, the metric associated with the semispray S is applied in order to study some types of foliations on the tangent bundle which are compatible with SODE structure. Indeed, suff...
متن کامل