Myocardial Protection, Perioperative Management, and Vascular Biology Rottlerin Increases Cardiac Contractile Performance and Coronary Perfusion Through BKCa Channel Activation After Cold Cardioplegic Arrest in Isolated Hearts
نویسندگان
چکیده
From the Cardiovascular Research Center, Department of Surgery, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI. Presented at the 2010 American Heart Association meeting in Chicago, IL, November 12–16, 2010. The online-only Data Supplement is available at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIRCULATIONAHA.110.012112/-/DC1. Correspondence to Richard T. Clements, PhD, Cardiovascular Research Center, Department of Surgery, Rhode Island Hospital and Alpert Medical School, Brown University, Coro 5.230, 1 Hoppin St, Providence, RI 02903. E-mail [email protected] © 2011 American Heart Association, Inc.
منابع مشابه
BKCa channel activation increases cardiac contractile recovery following hypothermic ischemia/reperfusion.
Mitochondrial Ca(2+)-activated large-conductance K(+) (BKCa) channels are thought to provide protection during ischemic insults in the heart. Rottlerin (mallotoxin) has been implicated as a potent BKCa activator. The purpose of this study was twofold: 1) to investigate the efficacy of BKCa channel activation as a cardioprotective strategy during ischemic cardioplegic arrest and reperfusion (CP/...
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