The Effects of Cyanate In Vitro on Red Blood Cell Metabolism and Function inFSickle Cell Anemia
نویسنده
چکیده
Received for publication 2 September 1971 and in revised form 15 October 1971. cyanate in treating and preventing the anemia and painful crises of sickle cell disease.
منابع مشابه
Effect of Thyroid Dysfunctions on Blood Cell Count and Red Blood Cell Indice
Abstract Background Thyroid hormones have a crucial role in metabolism and proliferation of blood cells. Thyroid dysfunction induces different effects on blood cells such as anemia, erythrocytosis leukopenia, thrombocytopenia, and in rare cases causes’ pancytopenia. It also alter RBC indices include MCV, MCH, MCHC and RDW. Thus this study attempted to evaluate effect of hypo & hyperthyroi...
متن کاملThe effects of cyanate in vitro on red blood cell metabolism and function in sickle cell anemia.
Cyanate, which is in equilibrium with urea, combines with the alpha-amino group of the aminoterminal valine of hemoglobin in an irreversible, specific carbamylation reaction. Partial carbamylation (0.72 residues/hemoglobin tetramer) as determined by cyanate-(14)C incorporation or hydantoin analysis diminishes the in vitro sickling phenomenon. Since cyanate may react not only with hemoglobin but...
متن کاملP-85: Evaluation of Sperm Fertility Quality in Phenyl Hydrazine-Induced Hemolytic Anemia Impacts on Mice
Background: Anemia and consequently low oxygen can cause changes in the function and structure of the testis and spermatogenesis, Iron released from red blood cells, followed by the increased oxidative stress, which may cause tissue iron. This study was designed to minimize the deleterious effects of hypoxia on the genitals. Materials and Methods: Eighteen mature male mice were randomly divided...
متن کاملInhibition of hemoglobin synthesis by cyanate in vitro.
Cyanate inhibits sickling and prolongs red cell cell was not impaired, and free intracellular survival in sickle cell anemia. However, cyanate amino acid was not carbamylated. Aminoacylamarkedly inhibits hemoglobin synthesis in vitro. tion of transfer RNA was not inhibited; the Incorporation of radioactive amino acid into acylated amino acid was not carbamylated. hemoglobin by human sickle reti...
متن کاملReticulocyte survival in sickle cell anemia: effect of cyanate.
Cyanate prevents sickling in vitro and apparently prolongs the survival of 51Cr-tagged sickle erythrocytes in vivo. Cautious interpretation is required because the effects of cyanate on 51Cr binding to sickle and fetal hemoglobincontaining red cells are unknown, and comparison of the effect of cyanate on sickle red cell survival to control red cell survival must be performed sequentially. We ha...
متن کامل