Cispentacin, a new antifungal antibiotic. I. Production, isolation, physico-chemical properties and structure.
نویسندگان
چکیده
A new antibiotic, cispentacin, was isolated from the culture broth of a Bacillus cereus strain, L450-B2. The antibiotic is water-soluble and amphoteric; its structure was determined by spectroscopic analysis and chemical synthesis to be (1R,2S)-2-aminocyclopentane-1-carboxylic acid. Cispentacin demonstrated only weak in vitro activity against certain fungi but strong protection of mice from lethal infection of Candida albicans A9540.
منابع مشابه
A novel antifungal antibiotic, FR-900848. I. Production, isolation, physico-chemical and biological properties.
Streptoverticillium fervens produced a new antibiotic, FR-900848, which has a high specific activity against filamentous fungi. Purified by solvent extraction and column chromatography, the compound appears as colorless crystals. Its structure is C32H43N3O6, which consists of 5'-amino-5'-deoxy-5,6-dihydrouridine with an unsaturated fatty acid having unprecedented four serial and one isolated cy...
متن کاملPapulacandins, a new family of antibiotics with antifungal activity, I. Fermentation, isolation, chemical and biological characterization of papulacandins A, B, C, D and E.
Papulacandin, a new antibiotic complex, active against Candida albicans and several other yeasts, was isolated from a strain of Papularia sphaerosperma. The fermentation, isolation, physico-chemical properties and biological activity of the five structurally related papulacandins A, B, C, D and E are reported. Papulacandin B, the main component, was assigned the formula of C47H64O17.
متن کاملIsolation, physico-chemical properties and structure elucidation studies on HA-2-91 , a new tetraene polyene antifungal antibiotic produced by Streptomyces arenae var ukrainiana
Polyene antibiotics a re characterized to have 26 to 38 membered macrocyclic lactone ring contain ing 3 to 8 conjugated double bonds t and most of them possess remarkable antifungal activity. The polyenes are grouped according to the number of double bonds present in the molecule and it has been rep.orted that the an tifungal activity increases s ignificantl y with the presence of more conjugat...
متن کاملAtpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties.
Penicillium sp. FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC. The molecular formula of atpenins A4, A5 and B were determined to be C15H22NO5Cl, C15H21NO5Cl2 and C15H23NO5, respectively,...
متن کاملYS-822A, a new polyene macrolide antibiotic. I. Production, isolation, characterization and biological properties.
A new polyene macrolide antibiotic, YS-822A was isolated from the culture filtrate of a mutant strain H-8 of Streptoverticillium eurocidicum var. asterocidicus S-822. Whereas the original S-822 strain produced not only YS-822 substances but also teleocidin as by-product which is well-known as a strong carcinogenic promoter, the mutagenized H-8 strain produced the antibiotic with only a trace am...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 42 12 شماره
صفحات -
تاریخ انتشار 1989