HER2 Ile655Val Single Nucleotide Polymorphism in Patients with Ovarian Cancer
نویسندگان
چکیده
BACKGROUND The association between HER2 Ile655Val single nucleotide polymorphism and cancer is controversial. OBJECTIVES The aim of our study was to investigate this polymorphism in patients with ovarian cancer. PATIENTS AND METHODS Genomic DNA was extracted from peripheral blood leukocytes of 107 patients and 130 healthy women. HER2 gene polymorphism was assessed by PCR-RFLP. RESULTS No significant difference was observed in genotype and allele frequency between patient and control groups according to HER2 Ile655Val polymorphism. The disease stage, age, and histological type were also not associated with the polymorphism. CONCLUSIONS Our data showed that HER2 Ile655Val single nucleotide polymorphism was not significantly associated with onset, histological type, age, and stage of ovarian cancer in Iranian patients.
منابع مشابه
Association between the HER2 Ile655Val polymorphism and response to trastuzumab in women with operable primary breast cancer.
BACKGROUND Human epidermal growth factor receptor 2 (HER2) Ile655Val polymorphism may affect the efficacy of trastuzumab treatment of breast cancer. PATIENTS AND METHODS HER2 Ile655Val polymorphism was determined in 4167 patients with primary breast cancer using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. We investigated the associations between the ...
متن کاملA bias in genotyping the ERBB2 (HER2) Ile655Val variant.
Dear Sir, As part of association studies on cancer risk ERBB2 Ile655Val is a frequently analysed polymorphism. Recent publications have analysed the association of the common ERBB2 single nucleotide polymorphism (SNP) Ile655Val with breast cancer risk using TaqMan allelic discrimination (1,2). However, this genotyping method appears to be inappropriate regarding Ile655Val as the adjacent varian...
متن کاملRole of HER-2 Ile655Val Polymorphism as Universal Cancer Susceptibility Marker among Different Cancers.
BACKGROUND Genetic and expression anomaly of HER-2 have been frequently observed in different cancers. However, an overall association of HER-2 polymorphism (Ile655Val) with available cancer studies has not yet been explored. In the present study, a probable correlation of HER-2 Ile655Val polymorphism with 6 major types of cancers including breast, lung, gastric, ovarian, thyroid and uterine ha...
متن کاملAssociation of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer
Oxidative stress is known to be one of the major factors involved in the development and progression of cancer. Oxidative stress can occur due to an imbalance between concentrations of reactive oxygen species and antioxidant capacities. Catalase (CAT; OMIM 115500) and superoxide dismutase 1 (SOD1; OMIM 147450) play important roles in the primary defense against oxidative stress. In the present ...
متن کاملStudy of Cytochrome P450 1A1 (T3801C) Single Nucleotide Polymorphism in Patients with Breast Cancer in Mazandaran Province-Northern Iran
Background: Breast cancer is the first leading cause of cancer-related death in women. Pesticides which are excessively used in northern Iran are one of the most important risk factors for breast cancer incidence. The cytochrome P450 1A1 (cyp1A1) is a key enzyme in xenobiotics metabolism and SNPs of its coding gene has been verified to be important in cancer susceptibility. The aim of thi...
متن کامل