Differentiation - dependent regulation of intestinal vitamin B 2 uptake : Studies utilizing 1 human - derived intestinal epithelial Caco 2 cells and native rat intestine
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چکیده
Differentiation-dependent regulation of intestinal vitamin B2 uptake: Studies utilizing 1 human-derived intestinal epithelial Caco2 cells and native rat intestine 2 3 Veedamali S. Subramanian , Abhisek Ghosal , Sandeep B. Subramanya , Christian Lytle, 4 and Hamid M. Said 2 5 Departments of Medicine, Physiology and Biophysics, University of California, Irvine, CA 6 92697; and Department of Medical Research, Veterans Affairs Medical Center, Long Beach, CA 7 90822, Division of Biomedical Sciences, University of California, Riverside, CA 92521 8 9 10 11 12 Running title: Regulatory aspects of intestinal riboflavin uptake 13 14 15 Correspondence: Hamid M. Said, UCI/VA Medical Program-151, Long Beach, CA90822; Tel. 16 562-826-5811, Fax. 562-826-5675. Email: [email protected] 17 18 19 20 21 22 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (February 14, 2013). doi:10.1152/ajpgi.00018.2013
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Differentiation-dependent regulation of intestinal vitamin B(2) uptake: studies utilizing human-derived intestinal epithelial Caco-2 cells and native rat intestine.
Intestinal epithelial cells undergo differentiation as they move from the crypt to the villi, a process that is associated with up- and downregulation in expression of a variety of genes, including those involved in nutrient absorption. Whether the intestinal uptake process of vitamin B(2) [riboflavin (RF)] also undergoes differentiation-dependent regulation and the mechanism through which this...
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