The multifunctional Ca /calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9
نویسندگان
چکیده
Jason A. Scott, Litao Xie, Hui Li, Weiwei Li, Julie B. He, Philip N. Sanders, A. Brent Carter, Johannes Backs, Mark E. Anderson, and Isabella M. Grumbach Departments of Medicine, Molecular Physiology and Biophysics, Free Radical and Radiation Biology Program, Radiation Oncology, Carver College of Medicine, University of Iowa; Iowa City VA Medical Center, Iowa City, Iowa; and Department of Internal Medicine III, University of Heidelberg, Germany
منابع مشابه
The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9.
The multifunctional CaMKII has been implicated in vascular smooth muscle cell (VSMC) migration, but little is known regarding its downstream targets that mediate migration. Here, we examined whether CaMKII regulates migration through modulation of matrix metalloproteinase 9 (MMP9). Using CaMKIIδ(-/-) mice as a model system, we evaluated migration and MMP9 regulation in vitro and in vivo. After ...
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