The efflux pump SmeDEF contributes to trimethoprim-sulfamethoxazole resistance in Stenotrophomonas maltophilia.

نویسندگان

  • María Blanca Sánchez
  • José Luis Martínez
چکیده

Trimethoprim-sulfamethoxazole (co-trimoxazole) is one of the antimicrobials of choice for the treatment of Stenotrophomonas maltophilia infections. The analysis of mutants either lacking or overexpressing the efflux pump SmeDEF shows that this efflux pump contributes to intrinsic and acquired co-trimoxazole resistance in S. maltophilia. Since SmeDEF can extrude a variety of antibiotics, selection with such antimicrobials, including quinolones, might also select for S. maltophilia co-trimoxazole resistance.

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The efflux pump SmeDEF contributes to trimethoprim / sulfamethoxazole 1 resistance in

The efflux pump SmeDEF contributes to trimethoprim/sulfamethoxazole 1 resistance in Stenotrophomonas maltophilia 2 3 María Blanca Sánchez and José Luis Martínez* 4 Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, 5 Darwin 3, Cantoblanco, 28049 Madrid, Spain. 6 7 Corresponding author’s mailing address: 8 JLM e-mail: [email protected] 9 10 11 12 13 14 15 16 17 1...

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A function of SmeDEF, the major quinolone resistance determinant of Stenotrophomonas maltophilia, is the colonization of plant roots.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 59 7  شماره 

صفحات  -

تاریخ انتشار 2015