Proliferation and Cytolytic Function of Anti - CD 3 + Interleukin - 2 Stimulated Peripheral Blood Mononuclear Cells Following Bone Marrow
نویسندگان
چکیده
We evaluated the proliferation, cytolytic function, and phenotypic characteristics of antLCD3 plus interleukin-2 (IL-2) stimulated peripheral blood mononuclear cells (PBMCs) from 44 patients with leukemia or non-Hodgkin's lymphoma (NHL) treated with multiagent chemotherapy or following bone marrow transplantation (BMT). BMT patients had decreased cell growth with only a 1.35 f 0.25 (autologous BMTfor acute lymphoblastic leukemia [ALL]), 1.24 f 0.25 (autologous BMT for NHL), and 0.8 f 0.1 (allogeneic BMT for leukemia) mean fold increase by day 5 of culture compared with controls (4.0 f 0.4). P < .001. Anti-CD3 + IL-2 activated cells from patients with ALL and NHL who had received autologous BMT and cells from patients with leukemia who underwent allogeneic BMT were more effective in lysing the natural
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