Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic -cells
نویسندگان
چکیده
Vasudeva Kamath,* Chandrashekara N. Kyathanahalli,* Bhavaani Jayaram, Ismail Syed, Lawrence Karl Olson, Katrin Ludwig, Susanne Klumpp, Josef Krieglstein, and Anjaneyulu Kowluru Department of Pharmaceutical Sciences, Wayne State University and Veterans Affairs Medical Center, Detroit; Department of Physiology, Michigan State University, East Lansing, Michigan; and Institute for Pharmacology and Medicinal Chemistry, Westfalische Wilhelms University, Münster, Germany
منابع مشابه
Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells.
We report localization of a cytosolic protein histidine phosphatase (PHP; approximately 16 kDa) in INS 832/13 cells, normal rat islets, and human islets. siRNA-mediated knockdown of PHP markedly reduced glucose- or mitochondrial fuel-induced but not KCl-induced insulin secretion. siRNA-mediated knockdown of PHP also attenuated mastoparan-induced insulin secretion, suggesting its participation i...
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