Reduction of Streptozotocin Toxicity by 3-O-Methyl-D-glucose with Enhancement of Antitumor Activity in Murine L1210 Leukemia1
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چکیده
The glucose moiety of SZ facilitates the uptake of its cytotoxic group 1-methyl-1-nitrosourea into islets (1). Re cently, prior administration of 3-0MG, a nontoxic nonme tabolizable derivative of glucose, has been shown to protect rats against the development of SZ-induced diabetes (5). We report the effect of 3-0MG pretreatment on the lethal and diabetogenic doses of SZ in normal mice and the effect of combination chemotherapy with 3-0MG and 30MG pIus nicotinamide on the therapeutic response of SZ in experimental L1210 lymphocytic leukemia.
منابع مشابه
Reduction of streptozotocin toxicity by 3-O-methyl-D-glucose with enhancement of antitumor activity in murine L1210 leukemia.
3-O-Methyl-D-glucose (3-OMG), a nontoxic nonmetabolizable derivative of glucose, is effective in reducing the toxicity of streptozotocin (SZ). In mice the administration of 3-OMG prior to SZ increased the dose that killed 50% of the animals from 240 to 340 mg/kg. Furthermore, the combination of 3-OMG plus nicotinamide (also effective in reducing SZ toxicity) increased the dose that killed 50% o...
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Structure-activity studies were performed to compare the biological and chemical activities of five methylnitrosoureas, including four compounds with substitution of the 1methyl-1-nitrosoureido group onto the carbon-1 or carbon2 position of glucose or galactose. Following equimolar i.p. injections to mice of doses that were lethal in 10% of them, all four sugar-containing analogs were found to ...
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