Hypertrophy and neuron loss: structural changes in sheep SCG induced by unilateral sympathectomy.

نویسندگان

  • Emerson T Fioretto
  • Sheila C Rahal
  • Alexandre S Borges
  • Terry M Mayhew
  • Jens R Nyengaard
  • Julio S Marcondes
  • Júlio C de Carvalho Balieiro
  • Carlos R Teixeira
  • Mariana P de Melo
  • Fernando V Lobo Ladd
  • Aliny A B Lobo Ladd
  • Ana R de Lima
  • Andrea A P da Silva
  • Antonio A Coppi
چکیده

Recently, superior cervical ganglionectomy has been performed to investigate a variety of scientific topics from regulation of intraocular pressure to suppression of lingual tumour growth. Despite these recent advances in our understanding of the functional mechanisms underlying superior cervical ganglion (SCG) growth and development after surgical ablation, there still exists a need for information concerning the quantitative nature of the relationships between the removed SCG and its remaining contralateral ganglion and between the remaining SCG and its modified innervation territory. To this end, using design-based stereological methods, we have investigated the structural changes induced by unilateral ganglionectomy in sheep at three distinct timepoints (2, 7 and 12 weeks) after surgery. The effects of time, and lateral (left-right) differences, were examined by two-way analyses of variance and paired t-tests. Following removal of the left SCG, the main findings were: (i) the remaining right SCG was bigger at shorter survival times, i.e. 74% at 2 weeks, 55% at 7 weeks and no increase by 12 weeks, (ii) by 7 weeks after surgery, the right SCG contained fewer neurons (no decrease at 2 weeks, 6% fewer by 7 weeks and 17% fewer by 12 weeks) and (iii) by 7 weeks, right SCG neurons were also larger and the magnitude of this increase grew substantially with time (no rise at 2 weeks, 77% by 7 weeks and 215% by 12 weeks). Interaction effects between time and ganglionectomy-induced changes were significant for SCG volume and mean perikaryal volume. These findings show that unilateral superior cervical ganglionectomy has profound effects on the contralateral ganglion. For future investigations, it would be interesting to examine the interaction between SCGs and their innervation targets after ganglionectomy. Is the ganglionectomy-induced imbalance between the sizes of innervation territories the milieu in which morphoquantitative changes, particularly changes in perikaryal volume and neuron number, occur? Mechanistically, how would those changes arise? Are there any grounds for believing in a ganglionectomy-triggered SCG cross-innervation and neuroplasticity?

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Dynamic changes of hemodynamic parameters and cardiac transcription of sirtuins in adaptive and mal-adaptive phases of pressure overload-induced hypertrophy in rats

Introduction: The aim of the study was to investigate the structural and hemodynamic changes as well as cardiac transcriptional profile of the key regulatory proteins, sirtuins family (SIRT1-7), in adaptive and mal-adaptive phases of left ventricular hypertrophy (LVH). Methods: LVH was induced in male Wistar rats (190±20g) by abdominal aortic banding. The third and sixteenth weeks post-surgery ...

متن کامل

Location of retrograde changes in the nervous system following unilateral lympathectomy in sheep.

The present paper is a continuation of our studies on the location of retrograde changes in the nervous system following unilateral sympathectomy in sheep (5). Our previous investigations showed that a majority (85%) of the fibres of the cervical sympathetic trunk run towards the anterior cervical ganglion, and about 15% of the fibres proceed from nerve cells situated nasal to the same ganglion...

متن کامل

Melissa officinalis aqueous extract ameliorates 6-hydroxydopamine-induced neurotoxicity in hemi-parkinsonian rat

ABSTRACT Background and Objective: Parkinson's disease (PD) is an age-related neurodegenerative disorder with massive loss of dopaminergic neurons in the substantia nigra pars compacta. L-Dihydroxyphenylalanine (L-DOPA) substitution is still the gold standard therapy for PD. However, there has been little information available on neuroprotective and regenerative therapies for PD. Due to the neu...

متن کامل

Comparison of Artificial Neural Network Training Algorithms for Predicting the Weight of Kurdi Sheep using Image Processing

Extended Abstract Introduction and Objective: Due to weakness, the occurrence of unwanted errors, the impact of the environment and exposure to natural events, human always make mistakes in their diagnoses of the environment or different topics, so that different people 's perception of a single and unique event may be very different and be diverse. Nowadays, with the development of image proc...

متن کامل

بررسی اثرات محافظتی پودر سیر بر عملکرد قلب هایپرتروفی شده ناشی از تستوسترون در موش صحرایی

Background and Objective: The androgens cause the cardiac hypertrophy and cardiomyopathy. There are reports of garlic protective effects in the cardiac hypertrophy due to overload and catecholamine. The aim of this study was to investigate the effects of garlic powder on testosterone-induced cardiac hypertrophy in rats. Materials and Methods: This experimental study was performed on Wistar mal...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

دوره 29 4  شماره 

صفحات  -

تاریخ انتشار 2011