Protein abnormalities in macrophages bearing asbestos.

Involvement of protein kinase C, phospholipase C, and protein tyrosine kinase pathways in oxygen radical generation by asbestos-stimulated alveolar macrophage.

Although asbestos stimulates oxygen radical generation in alveolar macrophages, the exact mechanism is still not clear. The purpose of this study was to compare the ability of three asbestos fibers (amosite, chrysotile, and crocidolite) to generate oxygen radicals in macrophages and examine the mechanism of this action. All asbestos fibers were able to induce chemiluminescence but chrysotile in...

بررسی منحنی های عملکرد ریوی در شاغلین کارخانه های تولید کننده محصولات سیمانی آزبستی

  Background and aims : Asbestos components are one of the most hazardous air pollutants that can cause a number of serious diseases in humanincluding asbestosis, lung cancer and mesothelioma . The main goal of this research was the assessment of occupational exposure effects with Asbestos fibers on pulmonary function and lung capacity disorders in worker of an Asbestos- cement pipe and plate m...

Asbestos Inhalation Induces Peroxynitrite Formation in the Rat Lung

To determine whether asbestos inhalation induces the formation of reactive nitrogen species, three groups of rats were exposed intermittently over 2 wk to either filtered room air (sham-exposed) or to chrysotile or crocidolite asbestos fibers. The rats were killed at 1 or 6 wk after exposure. At 1 wk, significantly greater numbers of alveolar and pleural macrophages from asbestos-exposed rats t...

Macrophages Protein-1 DNA Binding in Asbestos-Treated Factor-1 Nuclear Protein and Activator Oxidant-Mediated Increases in Redox

Internalization of Libby amphibole asbestos and induction of oxidative stress in murine macrophages.

The community members of Libby, MT, have experienced significant asbestos exposure and developed numerous asbestos-related diseases including fibrosis and lung cancer due to an asbestos-contaminated vermiculite mine near the community. The form of asbestos in the contaminated vermiculite has been characterized in the amphibole family of fibers. However, the pathogenic effects of these fibers ha...