TRANSFUSION MEDICINE Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non–transferrin-bound iron
نویسندگان
چکیده
Departments of 1Pathology and Cell Biology and 2Pediatrics and Medicine, Columbia University College of Physicians and Surgeons–New York Presbyterian Hospital, New York, NY; 3New York Blood Center, New York, NY; 4Aflac Cancer Center and Blood Disorders Service, Children’s Healthcare of Atlanta, Division of Pediatric Hematology/Oncology, Atlanta, GA; and 5Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA
منابع مشابه
Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.
Transfusions of RBCs stored for longer durations are associated with adverse effects in hospitalized patients. We prospectively studied 14 healthy human volunteers who donated standard leuko-reduced, double RBC units. One unit was autologously transfused "fresh" (3-7 days of storage), and the other "older" unit was transfused after 40 to 42 days of storage. Of the routine laboratory parameters ...
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